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KMID : 0939920220540010199
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대한암학회지
2022 Volume.54 No. 1 p.199 ~ p.207
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Association between the Persistence of Obesity and the Risk of Gastric Cancer: A Nationwide Population-Based Study
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Lim Joo-Hyun
Shin Cheol-Min
Han Kyung-Do
Lee Seung-Woo
Jin Eun-Hyo
Choi Yoon-Jin
Yoon Hyuk
Park Young-Soo
Kim Na-Young
Lee Dong-Hoon
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Abstract
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Purpose: There remains controversy about relationship between obesity and gastric cancer. We aimed to examine the association using obesity-persistence.
Materials and Methods: We analyzed a nationwide population-based cohort which underwent health check-up between 2009 and 2012. Among them, those who had annual examinations during the last 5 years were selected. Gastric cancer risk was compared between those without obesity during the 5 years (never-obesity group) and those with obesity diagnosis during the 5 years (non-persistent obesity group; persistent obesity group).
Results: Among 2,757,017 individuals, 13,441 developed gastric cancer after median 6.78 years of follow-up. Gastric cancer risk was the highest in persistent obesity group (incidence rate [IR], 0.89/1,000 person-years; hazard ratio [HR], 1.197; 95% confidence interval [CI], 1.117 to 1.284), followed by non-persistent obesity group (IR, 0.83/1,000 person-years; HR, 1.113; 95% CI, 1.056 to 1.172) compared with never-obesity group. In subgroup analysis, this positive relationship was true among those < 65 years old and male. Among heavy-drinkers, the impact of obesity-persistence on the gastric cancer risk far increased (non-persistent obesity: HR, 1.297; 95% CI, 1.094 to 1.538; persistent obesity: HR, 1.351; 95% CI, 1.076 to 1.698).
Conclusion: Obesity-persistence is associated with increased risk of gastric cancer in a dose-response manner, especially among male < 65 years old. The risk raising effect was much stronger among heavy-drinkers.
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KEYWORD
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Obesity, Stomach neoplasms, Dose-response relationship
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